- Sakai, Ayana
- Salenger, Meredith
- San Giacomo, Laura
- Sara, Mia
- Saram, Michelle
- Sarandon, Susan
- Satchwell, Brooke
- Sato, Aiko
- Saunders, Jennifer
- Sciorra, Annabella
- Scorsone, Caterina
- Scorupco, Izabella
- Scott, Ashley
- Scott, Melody Thomas
- Sedgwick, Kyra
- Seeberg, Xenia
- Segara, Helene
- Sen, Riya
- Sevigny, Chloe
- Seymour, Jane
- Shaw, Tracy
- Sheikh, Zara
- Shelton, Marley
- Shepard, Jewel
- Sheridan, Nicollette
- Shetty, Shilpa
- Shields, Brooke
- Shroff, Jackie
- Shue, Elisabeth
- Sigler, Jamie-Lynn
- Silva, Adele
- Silverman, Sarah
- Silverstone, Alicia
- Silvstedt, Victoria
- Simpson, Ashlee
- Sims, Molly
- Sirtis, Marina
- Sjoberg, Emma
- Sky, Jennifer
- Slater, Helen
- Smart, Amy
- Smith, Jaclyn
- Smith, Shawnee
- Sobieski, Leelee
- Sokoloff, Marla
- Somers, Suzanne
- Sorvino, Mira
- Soto, Talisa
- Spacek, Sissy
- Spelling, Tori
- Stanwyck, Barbara
- Steenburgen, Mary
- Stensgaard, Yutte
- Stephens, Adele
- Stiles, Julia
- Stone, Sharon
- Stowe, Madeleine
- Strang, Amanda
- Streep, Meryl
- Stringfield, Sherry
- Summer, Donna
- Suvari, Mena
- Swain, Dominique
- Swank, Hilary
- Swanson, Kristy
- Swinton, Tilda
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